Veterinary Vaccines and Diagnostics by Roland D. Schultz (Eds.)

By Roland D. Schultz (Eds.)

This quantity of Advances in Veterinary drugs , derived partially from the 1st Veterinary Vaccines and Diagnostic meetings, offers with vaccines, a particularly energetic region of veterinary learn and controversy.

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This is a moot question, of course, but for the virologist no prophetic talent is required to answer it in the positive sense. As long as cellular organisms populate this planet, new viruses will appear at regular intervals and infect them, at times making them ill. Consequently there will always be a reason for developing new vaccines--and there are no good alternatives. One may not expect universal antiviral chemotherapeutics, irrespective of the recent successes obtained in treating AIDS patients.

Although the injected DNA does not replicate, the induced immune reaction is similar to that after modified live vaccination, with respect to MHC class I antigen presentation and the induced cellular response. Protection is not only a function of the quality of the antigen but also of correct triggering of the immune system. To improve the immunogenicity of a preparation so-called adjuvants are added to the antigen; these are minerals such as aluminum hydroxide but also water/oil emulsions, detergents, plant glycosides, etc.

This is a depressing and dangerous situation, especially in view of the future developments in veterinary medicine. II. Will There Be Vaccination in the Next Millennium? This is a moot question, of course, but for the virologist no prophetic talent is required to answer it in the positive sense. As long as cellular organisms populate this planet, new viruses will appear at regular intervals and infect them, at times making them ill. Consequently there will always be a reason for developing new vaccines--and there are no good alternatives.

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